The 11 Best Enzyme Cleaners for Dog Urine

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Discover the power of an enzyme cleaner for dog urine, an effective and pet-friendly solution for those challenging spots. Enzyme cleaners use naturally occurring substances to break down the complex components in dog urine, such as uric acid, which can leave behind persistent stains and lingering smells. These unique products are designed to tackle the source of the problem, providing a deeper clean than traditional cleaning methods.
But how do you choose the right enzyme cleaner, and what factors should you consider? This guide will delve into the essential elements that make an enzyme cleaner effective, safe, and suitable for various surfaces like carpets and hardwood floors. We’ll explore common questions such as the safety of these cleaners around pets, their effectiveness compared to household solutions like vinegar, and their application on different pet stains. By the end, you’ll be well-equipped to handle any pet-related mess confidently and easily.

What Is Enzyme Cleaner?
An enzyme cleaner is a type of cleaning product that utilizes specific enzymes to break down complex biological substances, such as proteins, starches, and fats, into smaller, more manageable pieces. This allows these substances to be more easily wiped away or vacuumed up.
In relation to dog urine, enzyme cleaners are particularly effective. Dog urine contains uric acid, a compound that produces a strong, persistent odor and is not entirely dissolved by traditional cleaning methods. Enzyme cleaners contain enzymes called uricase, specifically designed to break down uric acid into its component parts, including carbon dioxide and water.
In addition to being effective cleaners, enzyme-based products are typically safer and more eco-friendly than chemical-based ones. They are less likely to cause harm to humans, animals, and the environment, which makes them a popular choice for pet parents looking to clean up after their dogs.
So, if you’re dealing with dog urine stains or odors, an enzyme cleaner could be an effective solution. By breaking down the uric acid and other organic materials in the urine, these cleaners can help to remove the stain and neutralize the odor.
What Enzyme Breaks Down Dog Urine?
The enzyme uricase (also known as urate oxidase) is particularly effective at breaking down uric acid, a primary component of dog urine that can cause lingering stains and smells. Uricase catalyzes the oxidation of uric acid to allantoin, a compound that is much more soluble in water and thus, easier to remove from surfaces.
Urine also contains proteins and other organic materials. Therefore, multi-enzyme cleaners, which include proteases to break down proteins, lipases to tackle fats, and amylases to break down carbohydrates, in addition to uricase, are usually the most effective solutions for dealing with pet stains and odors.
So, when looking for an enzyme cleaner for dog urine, you want to look for a product that mentions these types of enzymes in its list of ingredients. Always remember to check that the product is safe for the surface you intend to clean and is non-toxic and safe for pets and humans.
Buyer’s Guide: Factors to Consider When Choosing Enzyme Cleaner for Dog Urine
When choosing an enzyme cleaner for dog urine, consider the following factors:

Effectiveness: Check customer reviews and ratings to gauge if the product effectively removes stains and odors. Look for cleaners specifically designed for pet stains, as they’ll have the right enzymes to break down uric acid found in dog urine.
Safety: Ensure the cleaner is non-toxic and safe for use around pets and children. It should not contain any harmful chemicals or irritants.
Surface compatibility: Some cleaners are suitable for specific surfaces like carpets, hardwood, or tiles. Make sure the cleaner is compatible with the surface you plan to use it on.
Residue: Choose cleaners that don’t leave a sticky residue after use. A cleanser should remove the stain and leave the area looking as good as new.
Scent: Many cleaners have added fragrances. While some people might prefer a fresh scent to mask any residual odor, others might prefer an unscented cleaner. Choose according to your preference.
Eco-friendliness: Opt for biodegradable cleaners, which are better for the environment.
Price: Price could be a deciding factor. However, remember that a higher price doesn’t always guarantee a superior product, so consider other factors too.

Take your time when choosing an option, as enzyme cleaners typically cost a little more than other types of dog urine cleaners. And when it comes to cleaning dog urine, consider the following for the best results.

Tips For Cleaning Dog Urine
Age of the Stain:
Fresh urine stains are easier to clean as the urine has not yet dried, and the odorous compounds have not fully set into the material. Older, dried stains may require more time and repeated treatment.
Spot Test:
Before using a cleaning product on a larger area, do a spot test on a hidden section to check for any discoloration or damage.
Surface Material:
The type of surface matters. Carpets, hardwood floors, tiles, upholstery, and fabrics each have specific cleaning needs and restrictions. Always ensure your dog urine cleaner is safe to use on the material you’re treating.
Size of the Stain:
Larger stains may need more cleaner and could take longer to treat fully. Make sure to cover the whole affected area when applying the cleaner.
Urine can soak deep into carpets, upholstery, and even into subflooring. Make sure to apply enough cleaner to penetrate as deeply as the urine.
Drying Time:
After cleaning, make sure the area is allowed to dry completely to prevent moisture from causing mold or mildew.
In some cases, especially for older or larger stains, you may need to treat the area more than once to fully remove the stain and odor.
If using a commercial cleaner, ensure it is safe for use around pets and children, particularly if the cleaned area is one they frequently use.
Cleaning dog urine promptly and effectively is important not just for hygiene and aesthetics, but also because the scent of old urine can encourage dogs to urinate in the same spot again.
The 11 Best Enzyme Cleaners for Dog Urine
#1 – Rocco & Roxie Professional Strength Stain & Odor Eliminator
[affiliatable id=’194220′]
Rocco & Roxie Professional Strength Stain & Odor Eliminator has been recognized for its strong performance in eliminating stubborn dog urine stains and smells. It’s formulated with natural enzymatic bacteria that activate upon contact with odors and stains, feeding on ammonia crystals and organic matter to eliminate them. It’s also safe for a variety of surfaces, including carpets, furniture, and flooring. The product also has a pleasing scent, leaving your home smelling fresh after each use. Despite being powerful, it’s gentle and safe for both pets and children when used as directed.

Highly effective at removing dog urine stains and odors
Can be used on a variety of surfaces
Leaves a pleasant scent after cleaning
Non-toxic and safe around pets and children


May require multiple applications for older or deeper stains
Some users may not like the scent

#2 – Nature’s Miracle Stain and Odor Remover
[affiliatable id=’194223′]
Nature’s Miracle Stain and Odor Remover is renowned for its efficacy in tackling dog urine stains and associated odors. Its bio-enzymatic formula specifically targets pet messes to permanently remove unwanted stains and smells, effectively breaking down urine, feces, and vomit. The product is suitable for a multitude of surfaces, such as carpets, hard floors, and furniture. It leaves behind a light, fresh scent, which helps in odor control. Despite its potent cleaning power, Nature’s Miracle is safe for use around pets and kids when used as directed. This stain and odor remover is a trusted solution for pet parents seeking a reliable, pet-friendly cleaner.

Effectively breaks down urine, feces, and vomit
Suitable for a range of surfaces
Leaves a pleasant, clean scent
Safe to use around pets and children


May need multiple applications for heavier stains
Some users may find the scent too strong
Does not remove certain types of stains as effectively as others

#3 – Simple Solution Extreme Pet Stain and Odor Remover
[affiliatable id=’194227′]
Simple Solution Extreme Pet Stain and Odor Remover delivers impressive performance when dealing with dog urine. Its professional-strength formula uses pro-bacteria and enzymes that work together to break down, neutralize, and permanently eliminate stains and odors, making it especially effective against stubborn urine stains. It also features a multi-functional sprayer, ensuring targeted application on various surfaces such as carpets, upholstery, bedding, and other water-safe surfaces. The product has a refreshing scent, leaving the treated areas smelling clean and fresh. As potent as it is, it’s also safe to use around children and pets when used as directed. Simple Solution Extreme is a reliable choice for pet owners seeking a high-performing, user-friendly solution to tackle stubborn pet stains and odors.

Highly effective against stubborn stains and odors
Can be used on various water-safe surfaces
Leaves a pleasant, clean scent
Safe to use around pets and children


Might require repeated applications for older or larger stains
Although it has a pleasant smell, some users might find it overpowering

#4 – Angry Orange Stain Remover – 32oz Enzyme Pet Cleaner
[affiliatable id=’194232′]
Angry Orange Stain Remover – 32oz Enzyme Pet Cleaner is a potent solution to combat the challenges of dog urine stains and odors. Originating from oil found in orange peels, it offers a strong deodorizing ability, which is coupled with its enzymatic action to break down urine effectively. Its formula ensures that both fresh and set-in stains are tackled with equal efficiency, making surfaces look and smell as good as new. This cleaner’s citrus scent leaves a refreshing aroma behind, a welcome change from the unpleasant smells of pet messes. The product boasts of being both pet-friendly and child-safe, ensuring peace of mind for homeowners. With Angry Orange, pet owners can expect a refreshing, efficient, and reliable approach to pet stain and odor removal.

Powerful stain and odor removal capabilities
Pleasant and refreshing citrus aroma
Safe for pets and children when used as directed
Also available in a concentrated formula


Citrus scent might be overpowering for some users
May require multiple applications for deeply set-in stains

#5 – Urine Gone Stain & Odor Eliminator: Professional Strength Fast-Acting Enzyme-Based Solution
[affiliatable id=’194234′]
Urine Gone Stain & Odor Eliminator stands out with its professional strength, enzyme-based formula specifically designed to address dog urine challenges. Its fast-acting formula ensures stains and odors are broken down and eliminated swiftly, making it a favorite among pet parents seeking quick results. The enzymatic action dives deep into fibers and surfaces, ensuring a thorough clean that tackles even older, set-in stains. Beyond just cleaning, the product also leaves a neutral and fresh scent, replacing the pungent aroma of urine. Its user-friendly application process and its safety profile for pets and children make Urine Gone a comprehensive solution for homes with furry friends.

Swift action against dog urine challenges
Effective on a range of surfaces
Safe for children and pets when used as directed


May require reapplication for deeply ingrained stains
The neutral scent might not be strong enough for some users’ preference
Bottle spray mechanism can be improved for even application

#6 – Bubba’s Super Strength Commercial Enzyme Cleaner
[affiliatable id=’194238′]
Bubba’s Super Strength Commercial Enzyme Cleaner emerges as a formidable solution against the persistent issue of dog urine stains and odors. Employing a commercial-grade formula, it leverages the power of enzymes to break down and neutralize the urine’s organic matter, ensuring a thorough clean. Its strength makes it particularly effective on older, stubborn stains that other cleaners might struggle with. Beyond just cleaning, it also offers a pleasant, subtle fragrance that leaves spaces smelling refreshed. With its professional strength, it still maintains a safe profile, ensuring no harm to pets or children when used as per directions. Bubba’s Cleaner brings the potency of commercial cleaning into the comfort of home spaces, ensuring pet people can maintain a spotless, odor-free environment.

Delivers powerful cleaning results even on stubborn stains
Strong enough to break up old stains
Suitable for a variety of surfaces
Gentle scent refreshes the cleaned area without being overpowering


Might be pricier than some other options
Some users might prefer a stronger scent for masking heavier odors

#7 – Simple Green Bio Dog Active Stain & Odor Remover
[affiliatable id=’194242′]
Simple Green Bio Dog Active Stain & Odor Remover offers an eco-friendly solution to the persistent problem of dog urine stains and odors. Utilizing a bio-active formula, it penetrates deep into surfaces to break down and eradicate the very essence of pet messes. It effectively tackles both the stain and the pungent urine smell, leaving areas looking and smelling fresh. Its non-toxic, biodegradable nature stands out, ensuring the safety of pets, humans, and the environment. While gentle on the ecosystem, its cleaning power remains uncompromised, making it an excellent choice for environmentally-conscious pet owners. Simple Green Bio Dog presents a harmonious blend of efficiency and sustainability in pet stain and odor management.

Provides thorough cleaning while being environmentally responsible
Safe for pets, children, and the environment
Suitable for a wide range of surfaces


Might require a longer dwell time for older stains
Some users might find the scent not strong enough to mask heavier odors
The need for agitation or scrubbing in tougher spots

#8 – Sunny & Honey Pet Stain & Odor Miracle
[affiliatable id=’194243′]
Sunny & Honey Pet Stain & Odor Miracle – Enzyme Cleaner stands out as a reliable solution for the challenges presented by dog urine. Its enzyme-infused formula diligently breaks down the components of the urine, effectively eliminating both stains and the accompanying odors. Whether it’s a fresh accident or a stubborn, older stain, the product demonstrates impressive effectiveness. An added advantage is its pleasant fragrance, which leaves the treated areas smelling fresh. Moreover, the brand’s commitment to supporting animal rescues and no-kill shelters by donating a portion of their profits further elevates its appeal. Pet parents get a top-tier cleaning solution and contribute to a noble cause with every purchase.

Exceptional performance on dog urine stains and odors
Refreshing scent that lingers after cleaning
Environmentally friendly and safe for pets


Might require multiple applications for extremely old or deep stains
The scent, while pleasant, might be strong for some users
Price point might be slightly higher compared to other enzyme cleaners

#9 – AmazonCommercial Multi-Purpose Enzyme Cleaner
[affiliatable id=’194246′]
AmazonCommercial Multi-Purpose Enzyme Cleaner proves itself as a versatile and efficient solution to the problem of dog urine stains and odors. With its enzyme-powered formula, it actively breaks down the organic compounds found in urine, ensuring both the stain and accompanying odor are effectively eliminated. Its multi-purpose nature makes it suitable for a variety of surfaces, from carpets to hard floors, providing flexibility in its applications. The product is designed with a focus on delivering professional-grade results, making it a favorite among both households and commercial spaces. It offers a balanced blend of efficiency and affordability, making it a go-to choice for those seeking a cost-effective, reliable cleaner. With AmazonCommercial, users can expect a no-nonsense, effective approach to tackling pet messes.

Effectively tackles dog urine stains and odors
Versatile use on different surfaces
Delivers value for its price


Might require multiple applications for heavily stained areas
Lacks a distinct, pleasant post-cleaning scent

#10 – Zeiff Pro-Grade Multi-Purpose Probiotic Enzyme Cleaner
[affiliatable id=’194249′]
Zeiff Pro-Grade Multi-Purpose Probiotic Enzyme Cleaner stands out with its unique probiotic-infused approach to tackling dog urine messes. The enzyme and probiotic combination ensures a dual-action clean, breaking down urine stains while fostering a microbial balance that prevents future odors. This forward-thinking formula not only cleans but actively promotes a healthier environment on treated surfaces. Suitable for multiple surfaces, its versatility is commendable. The cleaner boasts of delivering professional-grade results, and its consistent performance is evident in its growing popularity. With Zeiff Pro-Grade, users are introduced to an innovative, effective method of managing pet stains and ensuring long-term freshness.

Unique probiotic approach for long-term odor management
Highly effective on dog urine stains and odors
Versatile application across different surfaces


Might be on the pricier side by volume compared to standard enzyme cleaners

#11 – Bissell Professional Pet Urine Eliminator + Oxy Carpet Cleaning Formula
[affiliatable id=’194251′]
The Bissell Professional Pet Urine Eliminator + Oxy Carpet Cleaning Formula, when used in a cleaning machine, provides an enhanced cleaning experience tailored for dog urine challenges. The formula harnesses the power of Oxy, which acts swiftly to break down and lift away both the stain and the unpleasant odor. As the machine circulates the solution through carpet fibers, the deep-cleaning action is thorough and noticeable, reviving carpets to their original splendor. This cleaner also possesses Scotchgard protection, ensuring future stains are kept at bay and prolonging the carpet’s fresh appearance. For machine-operated cleaning, the Bissell Professional formula emerges as a top contender, offering both immediate and long-term solutions to pet-related carpet woes.

Effective deep-cleaning action with noticeable results
Provides protection against future stains
Leaves carpets smelling fresh and looking revitalized


Specifically formulated for machines, limiting hand-clean applications
Some users might prefer a stronger scent for masking persistent odors
Might be pricier than some other machine-compatible solutions

FAQs About Dog Urine Cleaner with Enzymes
Is enzymatic cleaner safe for pets?
Yes, enzymatic cleaners are generally safe for pets. These cleaners use natural enzymes to break down stains and odors, and they typically don’t contain the harsh or toxic chemicals found in some traditional cleaning products. However, while the cleaner is in its wet phase and the enzymes are active, it’s best to keep pets away from the area. Once the cleaner has dried and done its job, it should be safe for your pet. As with any product, follow the manufacturer’s instructions for use and safety precautions.
Is enzyme cleaner better than vinegar for dog urine?
While vinegar can help to neutralize some of the odor of dog urine, an enzymatic cleaner is typically more effective. This is because the enzymes in these cleaners specifically target and break down the uric acid crystals found in dog urine, which are the primary cause of lingering smells. Vinegar, while useful for many cleaning tasks, cannot break down these crystals. Moreover, vinegar’s strong smell can be off-putting for some people.
Does dog urine cleaner remove the smell completely?
Quality dog urine cleaners, particularly those that use enzymes, are designed to eradicate the smell. They work by breaking down the odor-causing components of dog urine at a molecular level. This is unlike traditional cleaning products, which often just mask the smell. However, the effectiveness can depend on factors like the age and size of the stain, how deeply the urine has penetrated, and how long the cleaner is left to work.
How to use a dog urine cleaner?
To use a dog urine cleaner, start by blotting up as much of the urine as possible with paper towels if the stain is fresh. Then, apply the cleaner to the stained area according to the manufacturer’s instructions. This usually involves spraying or pouring the cleaner onto the stain and letting it sit for a set amount of time to allow the enzymes to work. Afterward, you may need to blot or rinse the area, or you may simply leave it to air-dry, depending on the specific product’s instructions.
Does enzyme cleaner work on other pet stains?
Yes, enzyme cleaners can work on a variety of pet stains. They can effectively break down feces, vomit, and other organic stains, in addition to urine. Different enzymes in these cleaners target different types of organic material, making them versatile cleaning tools for pet parents.
Can enzyme cleaner be used on hardwood floors and carpets?
Yes, enzyme cleaners can be used on both hardwood floors and carpets. Still, verifying this on the product’s label is crucial as some cleaners are formulated specifically for certain materials. Always choose a cleaner that clearly states it is safe for the surface you wish to clean. It’s also important to conduct a spot test on an inconspicuous area before treating the stain. This helps ensure the cleaner won’t cause discoloration or damage. Remember to follow the product’s instructions closely and take care not to over-saturate hardwood floors to avoid potential water damage.

Final Words
In conclusion, choosing and using an enzyme cleaner for dog urine can make a significant difference in maintaining a clean, odor-free home. Consider factors like effectiveness, safety, surface compatibility, and eco-friendliness when choosing a product. Armed with this knowledge, you can effectively tackle pet stains, ensuring a fresh and hygienic living environment for both you and your furry friend.
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